ACG, colorectal cancer, Digestive Disease Week 2021

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Healio Gastroenterology presents the following reports on the best peer-tested stories in May.

These stories include ACG guidelines for the preferred treatment of adults with Clostridioides difficile, updated recommendations from the US Preventive Services Task Force for colorectal cancer screening, coverage from Digestive Disease Week, and more.

ACG publishes guidelines for preferred treatment of C. difficile infection

ACG has developed guidelines for the preferred treatment of adults with Clostridioides difficile infection, published in the American Journal of Gastroenterology.

“These guidelines are timely – we have referenced new literature until the latest revision – and very clinically oriented. [Infectious Disease Society of America and Society of Healthcare Epidemiologists of America] published their own guidelines a few years ago,” Colleen R. Kelly, MD, told Healio Gastroenterology. “We aligned our severity categories with theirs — non-severe, severe and fulminant infection — and decided not to dive deep into epidemiology and infection control practices, which they covered well. Instead, we wanted an evidence-based, clinical to develop useful guideline for the diagnosis, treatment and prevention of C. difficile infection and chose to expand in areas of particular interest to gastroenterologists, including diagnostic issues surrounding diarrhea and distinguishing C. difficile colonization of active infection, and the evaluation and management of CDI in the setting of inflammatory bowel disease.” READ MORE.

USPSTF Provides Updated Colorectal Cancer Screening Recommendations

The US Preventive Services Task Force has issued updated recommendations for colorectal cancer screening in JAMA.

“Colorectal cancer is a devastating disease and the third leading cause of cancer death in the United States, yet about a quarter of adults ages 50 to 75 have never been screened for colorectal cancer. The Task Force reviews its recommendations approximately every 5 years to ensure they reflect the latest research.” Martha cubic, PhD, RN, professor and director of the School of Nursing in the College of Health and Human Services at George Mason University, a member of the US Preventive Services Task Force (USPSTF), Healio told me. “Screening for colorectal cancer is effective and saves lives. New science about colorectal cancer in people under the age of 50 has allowed us to extend our recommendation to people aged 45 to 49 years. Everyone aged 45 to 75 should be screened for colorectal cancer to reduce their risk of dying from this disease.” READ MORE.

Intake of sugar-sweetened beverages linked to early colorectal cancer

In women, higher intake of sugar-sweetened drinks in adulthood and adolescence correlated with a higher risk of early colorectal cancer, according to research published in Gut.

“Early-onset colorectal cancer (EO-CRC, age <50 years at diagnosis) is increasing rapidly in the US, with unclear understanding of etiology and contributors to the rise. Sugar-sweetened beverages (SSBs) have adverse metabolic effects throughout the life course, including insulin resistance and inflammation. Higher SSB intake was also associated with obesity, which was previously associated with the risk of EO-CRC," Yin Cao, MPH, ScD, Department of Public Health Sciences, Department of Surgery, Washington University School of Medicine, at Healio. “Thus, we expect that SSB may be an emerging risk factor for EO-CRC and likely contribute to the rising incidence of EO-CRC.” READ MORE.

Link found between family history of colorectal polyps, risk of colorectal cancer

Family history of colorectal polyps linked to higher risk of colorectal cancer in a Swedish cohort, according to research published in BMJ.

“Contrary to the identified increased risk associated with a family history of CRC, it remains unclear whether people with a family history of colorectal polyps are at increased risk for CRC. As a result, available screening recommendations are different for individuals with a family history of polyps,” Mingyang Song, MBBs, ScD, department of epidemiology and nutrition at Harvard TH Chan School of Public Health, and colleagues wrote. “Given the higher prevalence of polyps than CRC associated with the increasing uptake of endoscopic screening, a better understanding of the influence of family history of polyps on CRC risk is critical to improve current screening recommendations.” READ MORE.

Young IBD patients do not develop neutralizing antibodies to SARS-CoV-2

Of the young patients with inflammatory bowel disease, most who tested positive for SARS-CoV-2 had a non-neutralizing antibody, according to data presented at Digestive Disease Week.

“Rapid decline in antibody levels after SARS-CoV-2 infection in our IBD patients treated with biologics suggests a greater risk of reinfection, especially for variants that can escape the antibodies,” Joelynn daley, D.O., of Connecticut Children’s Medical Center, Hartford, said during her presentation. READ MORE.

Probiotics, Reducing Symptoms of Upper Respiratory Tract Infection

Daily use of probiotics correlated with a reduction in symptoms of upper respiratory tract infections in overweight individuals, according to a presentation from Digestive Disease Week.

“There is a growing body of evidence supporting the contribution of the gut-lung axis to find the relationship between the gut microbiome and respiratory immune responses,” Benjamin Mullish, MD, clinical lecturer in the Division of Digestive Diseases, Imperial College London, England, at a press conference prior to DDW. “Previous research in this area shows that probiotics can reduce upper respiratory tract infections (URTIs) in healthy adults and children; however, we have limited data on vulnerable populations, such as the elderly, overweight and obese people.” READ MORE.

Patients prefer FIT over blood work for CRC screening

When given a choice, participants preferred fecal immunochemical testing based on colorectal cancer screening compared to a blood test, according to research presented at Digestive Disease Week.

“Sub-optimal participation is common in CRC screening programs; few studies have addressed directly to non-participants to test strategies that may be effective in engaging them. Barriers include access to health care systems, belief in the value of screening, exposure to trusted attorneys, aversion to certain types of testing, and the inconvenience of running the screening system itself.” Graeme Young, physician, FRACP, Flinders Center for Innovation in Cancer, Flinders University, said. “Our previous studies have shown an overwhelming preference for a blood test over FIT for two-step screening. A blood test with screening could therefore improve participation, especially among non-participants who have previously offered FIT.” READ MORE.

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